In Pursuit of a Perfect TTO
How AI-powered infrastructure can plug the leaks in the global innovation pipeline and ensure that breakthrough research reaches the people who need it most.
The Innovation Pipeline Is Broken
Every year, the world invests over $700 billion in research and development1. This investment produces extraordinary discoveries — potential cures for diseases, solutions to climate change, technologies that could transform lives. Yet less than 5% of this research ever reaches the market.
The problem is not a lack of innovation. It is a systemic failure in the pipeline that connects research to real-world impact. A recent analysis by Renaissance Philanthropy has identified over 60 distinct failure points2 in the U.S. innovation ecosystem alone — and the United States has the most developed tech transfer infrastructure in the world.
$700B+
Global R&D annually
<5%
Ever commercialized
60+
Failure points (US)
The Crisis Is Global — and Unequal
Developed economies like the United States and United Kingdom often respond to innovation pipeline failures by pouring more resources into the system — more funding, more programs, more initiatives. But adding more water to leaky pipes doesn't fix the leaks. It simply increases the volume of what's lost.
Meanwhile, in much of the world, the pipes barely exist at all. Researchers in emerging economies face not just leaky infrastructure, but often no infrastructure whatsoever — no TTOs, no patent support, no pathway from lab to market.
Pipeline Integrity by Region
United States
Mature ecosystem
Robust TTO network; $4.1B licensing revenue (2022)3; established VC ecosystem; still loses most research to the 'valley of death'
United Kingdom
Concentrated excellence
£287M Intellectual Property income (2022-23)4; Golden Triangle dominance (Oxford, Cambridge, London); severe regional disparity; post-Brexit uncertainty
Europe
Fragmented
World-class research; €328B R&D investment5; 27+ fragmented national systems; inconsistent IP frameworks; persistent brain drain
Asia-Pacific
Rapidly growing
China now leads in research output6; nascent TTO infrastructure; cultural barriers to academic entrepreneurship; VC concentrated in few hubs
Global South
Critical gap
Minimal TTO infrastructure; 0.5% of global patents7; isolated researchers; locally-relevant innovations never commercialized; extreme talent exodus
The asymmetry is stark: a researcher in Boston with a breakthrough has access to institutional support, patent attorneys, licensing professionals, and investor networks. A researcher in Nairobi, São Paulo, or Manila with an equally important discovery often has none of these resources. Their only options are to abandon the work — or emigrate.
ttOS: AI Infrastructure for Global Tech Transfer
ttOS is building the AI-powered infrastructure to democratize tech transfer globally. Our approach addresses the pipeline leaks at every stage — from initial disclosure through successful commercialization.
Two-Layer Architecture
Free AI Bots for Everyone
Global AccessOur suite of AI bots provides every researcher — regardless of institution or geography — with world-class tech transfer guidance:
Disclosure
Bot
Autofill disclosure forms
Evaluation
Bot
Due diligence, prior art and market numbers
Protection
Bot
Patent draft and filing
Marketing
Bot
Highlights, Contact lists, Data Room
Licensing
Bot
Strategy, Negotiation and Execution
Platform for Institutions
Systemic ScaleOur institutional platform enables universities, research organizations, and governments to:
Streamline Workflows
Inventor dashboard and Caseview dashboard for real time updates
Coordinate IP Bundling
Combine complementary patents into more valuable packages
Agreement coordination
Standardized agreements that adapt to all jurisdictions. Compare and sign online
Connect to Markets
Match innovations with industry partners and investors globally
10x
Faster Processing
24/7
Available in any timezone
10+
Languages supported
Surfacing Hidden Innovation
One of the most persistent challenges in tech transfer is availability bias — the tendency to focus on innovations from researchers and labs already on the TTO's radar, while overlooking high-potential discoveries elsewhere.
Eliminating Blind Spots
Surface Overlooked Innovations
ttOS proactively identifies innovations researchers themselves might miss — discoveries with commercial potential that would otherwise remain buried in academic publications or lab notebooks.
Level the Playing Field
Labs with high innovation potential can be overlooked if PIs aren't well-connected or at prestigious institutions. ttOS eliminates this availability bias by identifying potential regardless of institution size or location.
Prevent Lost Opportunities
Every overlooked innovation is a lost opportunity — for the researcher, the institution, and society. ttOS ensures that promising discoveries don't fall through the cracks simply because they weren't visible to the right people at the right time.
An important capability: while the core mission of ttOS is to streamline the tech transfer process, this ability to surface hidden innovation represents a meaningful additional benefit — helping institutions discover value they didn't know they had.
Potential for Systemic Impact
By plugging the leaks in the global innovation pipeline, investment in ttOS can generate cascading benefits across the entire research-to-impact ecosystem:
1,000+
Potential new startups per year from research that would otherwise be lost to the 'valley of death'
$50B+
Estimated annual value of research currently lost due to commercialization failures globally
100K+
Researchers in underserved regions who could gain access to world-class tech transfer guidance
10x
Potential increase in IP discovery rate by eliminating availability bias and surfacing hidden innovations
The multiplier effect : every researcher who successfully commercializes their work creates jobs, generates tax revenue, attracts further investment, and inspires the next generation. By fixing the infrastructure, strategic investment doesn't just fund one innovation — it unlocks an entire ecosystem.
The Opportunity for Partners
We are seeking partners who share our vision of a brighter future through science, technology, and innovation. Partners who understand that:
- 1
Infrastructure investments compound. Building the rails for innovation creates returns that grow over decades, not quarters.
- 2
Global challenges need global solutions. Climate change, pandemics, and food security require innovation from everywhere, not just elite institutions in wealthy countries.
- 3
AI can democratize expertise. What once required expensive professionals can now be delivered at scale to anyone with an internet connection.
- 4
Systemic change creates lasting value. Strategic partners can drive impact that extends far beyond any single investment or initiative.
Join Us in Plugging the Leaks
Together, we can ensure that breakthrough research — wherever it originates — has a pathway to impact. We can build the infrastructure that transforms the global innovation pipeline from a system of loss to a system of abundance.
Contact us to discuss partnership opportunities and learn more about our work.